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Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)

NCT03704415 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 97

Last updated 2025-03-18

No results posted yet for this study

Summary

This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs. The investigators want to see if patients with certain clinical and/or genetic predispositions will benefit from extended surgery. They also aim to find biomarkers for detection and management models for of severe airway inflammation and to further develop markers for progressive disease forms.

Conditions

  • Sinusitis, Chronic
  • Asthma
  • Nasal Polyps
  • Aspirin Sensitivity

Interventions

PROCEDURE

Extended endoscopic sinus surgery

ESS of all sinuses

PROCEDURE

Limited endoscopic sinus surgery

Partial ethmoidectomy

Sponsors & Collaborators

  • Helsinki University Central Hospital

    lead OTHER

Principal Investigators

  • Paula Virkkula, Docent · Helsinki University Central Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-23
Primary Completion
2024-10-23
Completion
2024-10-23

Countries

  • Finland
  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03704415 on ClinicalTrials.gov