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The Effect of Modified Radical Endoscopic Sinus Surgery on Eosinopilic Chronic Rhinosinusitus With Nasal Polyps

NCT04852562 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2025-09-10

No results posted yet for this study

Summary

Functional endoscopic sinus surgery (FESS) is the pimary surgical treatment of CRS, characterized with the preservation of nasal structure and function.But the control of disease by surgery has been unsatisfactory. Recent studies have shown that patients with recurrent CRSwNP (usually with severe eosinophilic inflammation), more radical surgery may be more effective. The purpose of this prospective and randomized study is to determine the effect of endoscopic sinus surgery for extensive mucosal removal in patients with eosinophilic chronic rhinosinusitus with nasal polyps.

Conditions

  • Chronic Sinusitis
  • Endoscopic Sinus Surgery
  • Nasal Polyps

Interventions

PROCEDURE

Modified radical endoscopic sinus surgery

Modified radical endoscopic sinus surgery was performed to remove the mucosa including ethmoid sinus and maxillary sinus, as well as a completly middle turbinate.

PROCEDURE

functional endoscopic sinus surgery

Full maxillary antrostomy, ethmoidectomy, sphenoidotomy and frontal sinusotomy, but with the middle turbinate preservation.

Sponsors & Collaborators

  • Wuhan Central Hospital

    collaborator OTHER

  • Wuhan No.1 Hospital

    collaborator OTHER

  • Tianyou Hospital Affiliated to Wuhan University of Science and Technology

    collaborator OTHER

  • Wuhan Third Hospital

    collaborator OTHER

  • Wuhan Pu-Ai Hospital

    collaborator OTHER

  • Zheng Liu

    lead OTHER

Principal Investigators

  • Zheng Liu, Doctor · Huazhong University of Science and Technology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-06
Primary Completion
2024-07-26
Completion
2024-07-26

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04852562 on ClinicalTrials.gov