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Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls

NCT03703934 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2021-01-05

No results posted yet for this study

Summary

In this trial different parts of the pain signalling system involved in two rheumatic diseases - painful hand osteoarthritis and psoriatic arthritis, is examined. These measurements will be compared to those of healthy volunteers

The hypothesis is that patients with hand osteoarthritis and psoriatic arthritis react differently to painful and non-painful stimuli compared with the healthy volunteers.

The aim is to recruit 66 patients with painful hand-osteoarthritis, 66 patients with painful psoriatic arthritis and 66 healthy subjects not currently suffering from any pain conditions.

After completing an informed consent form subjects will participate in a single clinical visit. The pain signalling system is examined using pressure algometry and cuff algometry. A pressure algometer is a pistol shaped device that elicits pressure through a rod and a cuff algometer is akin to a blood pressure cuff. Different thresholds will be measured, such as when the sensation of pressure becomes painful and when the painful pressure becomes unbearable.

Participants will also get hand strength tested, have their joints examined and answer questionnaires regarding daily function and quality of life.

Furthermore participants will get blood drawn which is analysed for the presence of markers of inflammation and joint degeneration.

Conditions

  • Arthritis, Psoriatic
  • Hand Osteoarthritis

Sponsors & Collaborators

  • Aalborg University

    collaborator OTHER

  • Aalborg University Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-20
Primary Completion
2021-04-01
Completion
2021-07-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03703934 on ClinicalTrials.gov