Clinical Study Comparing 7 ENDS Products and 1 Combustible Cigarette Using 2 Delivery Methods.

Summary

A Randomized Study Comparing Nicotine Pharmacokinetics of Seven Electronic Cigarette Products and One Traditional Cigarette Across Two Delivery (10 puff and ad- libitum) Conditions, in Healthy Adult Smokers

Conditions

• Nicotine Dependence
• Nicotine Dependence, Cigarettes
• Tobacco Use
• Tobacco Smoking

Interventions

OTHER

JUUL Virginia Tobacco flavored 5.0% ENDS

Virginia Tobacco Flavored 5.0% ENDS product is administered using a controlled method and adlibitum

OTHER

PMI iQOS Heat sticks

PMI IQOS Heat sticks is administered using a controlled method and ad-libitum

OTHER

Reynolds VUSE Solo ENDS - Original

Reynolds VUSE solo ENDS - Original is administered using a controlled method and ad-libitum

OTHER

Imperial MyBlu ENDS - Original

Imperial MyBlu ENDS- original is administered using a controlled method and ad-libitum

OTHER

Altria MarkTen ENDS - Bold Classic

Altria MarkTen ENDS - Bold Classic is administered using a controlled method and ad-libitum

OTHER

MLV PHIX ENDS - Original Tobacco

MLV PHIX ENDS - Original Tobacco is administered using a controlled method and ad-libitum

OTHER

NJOY Daily EXTRA ENDS - Rich Tobacco

NJOY Daily EXTRA ENDS - Rich Tobacco is administered using a controlled method and ad-libitum

OTHER

Altria Marlboro combustible cigarette - Red

Altria Marlboro combustible cigarette - Red is administered using a controlled method and ad-libitum

Sponsors & Collaborators

• Juul Labs, Inc.

  lead INDUSTRY

Principal Investigators

• Concetta Carbonaro · JUUL

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

60 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-12-04

Primary Completion

2019-02-24

Completion

2019-04-09

Countries

• New Zealand

Study Locations