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A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems

NCT07323563 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-01-07

No results posted yet for this study

Summary

This will be an open-label, randomized, single-site, 8-way crossover study designed to evaluate plasma nicotine pharmacokinetic (PK) parameters and overall product liking (OPL) following an ad libitum use of Electronic Nicotine Delivery System (ENDS) investigational products (IPs) in a confinement setting by generally healthy adult combustible cigarette smokers and smokers who also use ENDS products.

Conditions

  • Smoking
  • Smoking Behaviors
  • Tobacco Use
  • Tobacco Smoking

Interventions

OTHER

Product G

Fruit Flavor, 5%

OTHER

Product H

Fruit Flavor, 5%

OTHER

Product C

Tobacco Flavor, 5%

OTHER

Product D

Fruit Flavor, 5%

OTHER

Product E

Fruit Flavor, 5%

OTHER

Product F

Fruit Flavor, 5%

OTHER

Product A

Menthol Flavor, 5%

OTHER

Product B

Mint Flavor, 5%

Sponsors & Collaborators

  • RAI Services Company

    lead INDUSTRY

Principal Investigators

  • Milly Kanobe · Reynolds American

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-15
Primary Completion
2026-05-15
Completion
2026-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07323563 on ClinicalTrials.gov