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Nicotine Pharmacokinetics of THS Single Use of a Regular or a Menthol Stick Compared to CIG

NCT05789420 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2024-11-22

Study results available
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Summary

The purpose of this study was to describe the nicotine pharmacokinetic (PK) profile during and after single use of THS (Induction heating technology, with either a regular or menthol stick) compared to singular CIG smoking in healthy adult subjects. In addition, pharmacodynamic effects (subjective effects) were evaluated to provide further insights on product acceptance and likelihood to use the THS again. Safety was assessed throughout the study.

Conditions

  • Smoking, Tobacco

Interventions

OTHER

P1R stick

Regular flavor tobacco stick

OTHER

P1M stick

Mentholated flavor tobacco stick

OTHER

CIG

Subjects' preferred brand of commercially available, regular or mentholated cigarettes

Sponsors & Collaborators

  • Philip Morris Products S.A.

    lead INDUSTRY

Principal Investigators

  • Xavier Jaumont, MD · Philip Morris Products S.A.

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-16
Primary Completion
2023-04-02
Completion
2023-05-05

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05789420 on ClinicalTrials.gov