MedTrace Logo

NSAIDs vs. Coxibs in the Presence of Aspirin

NCT03699293 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2026-05-14

Study results available
· View outcomes & findings →

Summary

The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial function.

Conditions

Interventions

DRUG

celecoxib 200mg capsule

celecoxib 200mg twice a day for 4 weeks

DRUG

naproxen sodium 550mg tablet

naproxen sodium 550mg twice a day for 4 weeks

DRUG

Aspirin 81mg tablet

81mg aspirin for 4 weeks in the run-in period, and for 8 weeks during treatment and crossover period

Sponsors & Collaborators

  • Platelet and Thrombosis Research, LLC

    lead OTHER

Principal Investigators

  • Paul Gurbel, MD · LifeBridge Health

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-22
Primary Completion
2022-12-01
Completion
2023-01-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03699293 on ClinicalTrials.gov