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Platelet Inhibition by Aspirin, Acetaminophen and NSAID

NCT00536068 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2007-09-28

No results posted yet for this study

Summary

Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.

Conditions

  • Hemostasis

Interventions

DRUG

Acetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo

1. Acetylsalicylic acid 100mg/po and acetaminophen 3x1g/po for 4 days 2. Acetylsalicylic acid 100mg/po and diclofenac 3x50mg/po for 4 days 3. Acetylsalicylic acid 100mg/po and naproxen 3x250mg/po for 4 days 4. Acetylsalicylic acid 100mg/po and placebo 3x1/po for 4 days

Sponsors & Collaborators

  • Kantonsspital Graubünden

    lead OTHER

Principal Investigators

  • Walter H Reinhart, MD Professor · Department of Internal Medicine, Kantonsspital Graubunden CH7000 Chur Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-08-31
Completion
2007-08-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00536068 on ClinicalTrials.gov