MedTrace Logo

Brain Excitability and Connectivity in Sensory-motor Pathways in ALS

NCT03694132 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 52

Last updated 2025-11-18

No results posted yet for this study

Summary

The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.

The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).

Conditions

Interventions

DEVICE

functional MRI

conditioning brain activity with peripheral stimulations

DEVICE

structural MRI

diffusion MRI and tractography for evaluating the brain structures

DEVICE

EEG/MEG

conditioning brain activity with peripheral stimulations

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    lead OTHER_GOV

Principal Investigators

  • Pierre-Francois Pradat, MD, PhD · Assistance Publique - Hôpitaux de Paris

  • Veronique Marchand-Pauvert, PhD · Institut National de la Santé Et de la Recherche Médicale, France

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-11-26
Primary Completion
2019-12-31
Completion
2021-03-31

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03694132 on ClinicalTrials.gov