Reversal of Atrial Substrate to Prevent Atrial

Summary

A multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on recurrence of atrial fibrillation.

Conditions

• Atrial Fibrillation

Interventions

OTHER

Aggressive Risk Factor Control

1. Sleep apnea screening, therapy is recommended if apopnea-hypopnea (AHI) index is greater than 15, with a target index of less than 5. 2. Counseling regarding alcohol reduction to 2 drinks/day for men, 1 drink/day for women, no binge drinking (\>5 drinks at one setting). 3. Participation in a 12 week structured, home-based exercise program and nutritional counseling. Weight reduction will be emphasized through modification of diet and exercise. 4. Blood Pressure management to achieve a target systolic blood pressure (SBP) of \<120/80 mm/Hg 5. Smoking cessation facilitated through local resources already established at each site

OTHER

Standard of Care

Recommendations based on current guidelines

Sponsors & Collaborators

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• Abbott

  collaborator INDUSTRY

• Philips Healthcare

  collaborator INDUSTRY

• Cardiac Arrhythmia Network of Canada

  collaborator OTHER

• Nova Scotia Health Authority

  lead OTHER

Principal Investigators

• John Sapp · Nova Scotia Health Authority

• Isabelle vanGelder · University of Groningen

• Ratika Parkash · Nova Scotia Health Authority

• Allan Skanes · London Health Sciences Centre

• Chris Blanchard · Nova Scotia Health

• David Birnie · University of Ottawa Heart Institution

• George Wells · University of Ottawa Heart Institution

• Michiel Rienstra · University of Groningen

• Jeff Healey · Hamilton Health Sciences Centre

• Jennifer Reed · University of Ottawa Heart Institution

• Anthony Tang · London Health Sciences Centre

• Vidal Essebag · McGill University Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-07-01

Primary Completion

2027-09-15

Completion

2027-12-31

Countries

• Canada

Study Locations