Clinical Outcomes of MP Persona vs. Persona Knee-PS

Summary

Knee osteoarthritis (OA) is a highly prevalent condition that results in substantial pain and loss of function. The end stage treatment for knee OA is total knee arthroplasty (TKA), a common and safe procedure typically performed for relief of symptoms. However, an increasing number of patients are complaining about their TKA due to altered sensations between their previous joint and the implant. Although several designs have been proposed to improve these outcomes, the knee kinematics after TKA remains different from physiological kinematics. The Medial Pivot TKA design was introduced to closely mimic normal knee kinematics and create the natural feeling of the knee. This study is intended to evaluate the clinical effectiveness and ability to restore knee motion of two TKA devices: the Medial Pivot Persona TKA Zimmer design with the traditional Zimmer Persona Knee-PS. The investigator's hypothesis is that the Medial Pivot design will results in better patient outcomes and restore knee motion at natural parameters.

Conditions

• Osteoarthritis, Knee

Interventions

DEVICE

Zimmer MP Persona

The medial pivot Persona® knee implant with a Medial Congruent™ Bearing

DEVICE

Zimmer Persona Knee-PS

Persona the personalized knee system

Sponsors & Collaborators

• Jewish General Hospital

  collaborator OTHER

• McGill University

  collaborator OTHER

• Zimmer Biomet

  collaborator INDUSTRY

• Montreal General Hospital

  collaborator OTHER

• Lady Davis Institute

  lead OTHER

Principal Investigators

• John Antoniou, MD, PhD · Jewish General Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-09-01

Primary Completion

2025-12-31

Completion

2026-06-30

FDA Device

Yes

Countries

• Canada

Study Locations