Study and Monitoring of Early Undifferentiated Arthritis

Summary

The French Society of Rheumatology initiated a large national multicenter, longitudinal and prospective cohort, ESPOIR, in order to set up databases to allow various investigations on diagnosis, prognostic markers, epidemiology, pathogenesis and medico-economic factors in the field of early arthritis and rheumatoid arthritis.

The primary objective is to set-up a multicentre cohort of early arthritis (less than 6 months) in France that could serve as a database to studies of various natures.

Specific objectives are in the following domains:

* diagnosis: to help determine among clinical, biological, radiographic and immunogenetics those parameters allowing for the earliest diagnosis classification as possible, in order to target early therapy;
* prognosis: to identify early those patients at risk of severe disease by investigating among clinical, biological, genetic and sociologic factors;
* medico-economic: to identify the costs and their determinants at various disease stage;
* pathologic: to collect a databank of sera, DNA, RNA to allow for studies of transcriptomes and other genomics.

Secondary objectives are twofold:

* to monitor adverse events, particularly rare drug adverse events, in collaboration with other international studies
* to allow access to the data collected in this cohort study in order to facilitate new projects submitted to and approved by the scientific committee.

Conditions

• Early Rheumatoid Arthritis or Early Undiffentiated Arthritis

Sponsors & Collaborators

• Amiens University Hospital

  collaborator OTHER

• University Hospital, Bordeaux

  collaborator OTHER

• University Hospital, Brest

  collaborator OTHER

• University Hospital, Lille

  collaborator OTHER

• University Hospital, Montpellier

  collaborator OTHER

• Saint Antoine University Hospital

  collaborator OTHER

• Pitié-Salpêtrière Hospital

  collaborator OTHER

• Hôpital Cochin

  collaborator OTHER

• Bicetre Hospital

  collaborator OTHER

• Bichat Hospital

  collaborator OTHER

• University Hospital, Rouen

  collaborator OTHER

• University Hospital, Strasbourg, France

  collaborator OTHER

• University Hospital, Toulouse

  collaborator OTHER

• University Hospital, Tours

  collaborator OTHER

• Societe Francaise de Rhumatologie

  lead OTHER

Principal Investigators

• Bernard COMBE, MD, PHD · Montpellier University Hospital rheumatology department

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-11-13

Primary Completion

2005-04-19

Completion

2025-07-13