The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
NCT03659513 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 75
Last updated 2023-07-27
Summary
This study will examine the pharmacokinetics of the various, routinely given antibiotics, sedatives, and opioids in patients undergoing venous-venous extra-corporal oxygenation (ECMO). Little is known about the distribution and effectiveness of antibiotics in this particular patient population.
Conditions
- Hypoxia
- Extracorporeal Membrane Oxygenation Complication
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
Jacob Gutsche, MD · University of Pennsylvania
-
Krzysztof Laudanski, MD, PhD · University of Pennsylvania
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2016-09-13
- Primary Completion
- 2022-10-24
- Completion
- 2022-10-24
Countries
- United States
Study Locations
More Related Trials
-
ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction
NCT04476173 ·Status: UNKNOWN ·Phase: PHASE3
-
Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting
NCT02303847 ·Status: UNKNOWN ·Phase: PHASE3
-
Efficacy and Safety of Oxmorphone Extended Release in Chronic Non-malignant Pain
NCT00225797 ·Status: COMPLETED ·Phase: PHASE3
-
Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function
NCT03616639 ·Status: TERMINATED ·Phase: PHASE4
-
Oxymorphone Extended Release (ER) in Opioid-Naive Patients With Chronic Pain
NCT00911287 ·Status: COMPLETED ·Phase: PHASE3
-
Oxymorphone Extended Release in Patients With Cancer or Neuropathic Pain
NCT00911261 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle
NCT05856136 ·Status: RECRUITING ·Phase: PHASE4
-
Prescription Medication Interactions
NCT04315181 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).
NCT01750060 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics Study of ALO-02 and OxyContin
NCT01557257 ·Status: COMPLETED ·Phase: PHASE1
-
Ketamine Patient-Controlled Analgesia for Acute Pain
NCT02062879 ·Status: TERMINATED ·Phase: PHASE3
-
Pharmacokinetics and Pharmacodynamics of TRV130, Morphine, and Placebo in Healthy Subjects
NCT02083315 ·Status: COMPLETED ·Phase: PHASE1
-
Impact of a Pharmaceutical Interview at the Initiation of Opioid Treatment for Acute Non-cancer Pain
NCT07049796 ·Status: COMPLETED
-
Fentanyl Patch Pharmacokinetics in Healthy Adults
NCT02531971 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Oxymorphone Extended Release in Opioid-Experienced Patients With Chronic Non-Malignant Pain
NCT00226421 ·Status: COMPLETED ·Phase: PHASE3
-
Cannabis Vs Opioids Pain Management Objective Testing Comparisons
NCT03734731 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
A Study to Assess the Relative Bioavailability of 4 Formulations of Fentanyl Transdermal System Compared Against DUROGESIC Fentanyl Transdermal Patch After Single Application in Healthy Volunteers
NCT01717157 ·Status: COMPLETED ·Phase: PHASE1
-
Predictors of Postoperative Pain Following Oocyte Retrieval for Assisted Reproduction
NCT03105518 ·Status: UNKNOWN ·Phase: PHASE4
-
Fentanyl Sublingual Spray and Fentanyl Citrate Intravenous (IV) in Opioid Naive Subjects
NCT02576353 ·Status: COMPLETED ·Phase: PHASE1
-
Ancillary Effects of Oral Naloxegol (Movantik)
NCT03235739 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.
NCT06966869 ·Status: RECRUITING
-
Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain
NCT02866071 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study on Oral and Intranasal Forms of Oxycodone in Healthy Volunteers Using Pharmacokinetic Modeling
NCT07223450 ·Status: COMPLETED ·Phase: PHASE1
-
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
NCT04218409 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Study to Evaluate the Efficacy and Safety of ORAVESCENT Fentanyl Citrate for the Management of Breakthrough Pain
NCT00214955 ·Status: COMPLETED ·Phase: PHASE3