Glucagon-like Peptide-1 Levels, Insulin Resistance and Insulin Sensitivity Index in Type 2 Diabetes Mellitus
NCT03659461 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 174
Last updated 2022-03-15
Summary
This study is conducted to examine GLP-1, insulin resistance and insulin sensitivity portfolio in Malay, Chinese and Indian populations in Malaysia and to study the effect of DPPIV inhibitor in T2DM patients with different GLP-levels.
Conditions
Interventions
- DRUG
-
Sitagliptin
oral 100mg Sitagliptin daily will be given for 12 weeks. Subjects are required to undergo OGTT pre and post treatment.
Sponsors & Collaborators
-
National University of Malaysia
lead OTHER
Principal Investigators
-
Kamaruddin Nor Azmi · National University of Malaysia
-
Shiau Chin Chong · National University of Malaysia
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2017-10-01
- Primary Completion
- 2019-12-31
- Completion
- 2020-01-31
Countries
- Malaysia
Study Locations
More Related Trials
-
Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus
NCT01235819 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus
NCT00551590 ·Status: COMPLETED ·Phase: PHASE1
-
Glimepiride, Empagliflozin, and Sitagliptin With Metformin for Type 2 Diabetes
NCT06759922 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of an Investigational Drug Sitagliptin for Type 2 Diabetes Mellitus (0431-044)
NCT00127192 ·Status: COMPLETED ·Phase: PHASE2
-
Usage of Dapagliflozin in the Management of Type-2 Diabetes Mellitus: A Real World Evidence Study in Indian Patients
NCT03071016 ·Status: COMPLETED
-
Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese Type 2 Diabetics
NCT01610154 ·Status: COMPLETED ·Phase: PHASE4
-
Comparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes Mellitus
NCT01652729 ·Status: COMPLETED ·Phase: PHASE3
-
Study of Chiglitazar Compare With Sitagliptin in Type 2 Diabetes Patients
NCT02173457 ·Status: COMPLETED ·Phase: PHASE3
-
Effects of Sitagliptin on Type 2 Diabetes Mellitus Patients on Treatment With Metformin and Insulin
NCT01341717 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Sitagliptin in Impaired Glucose Tolerance
NCT00961363 ·Status: UNKNOWN ·Phase: PHASE2
-
SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients)
NCT03108521 ·Status: COMPLETED ·Phase: PHASE4
-
Sitagliptin Mechanism of Action Study in Patients With Type 2 Diabetes Mellitus (0431-059)
NCT00704132 ·Status: COMPLETED ·Phase: PHASE1
-
To Assess Safety of Fixed Dose Combination of Dapagliflozin and Saxagliptin in Type 2 Diabetes Mellitus Patients
NCT04445714 ·Status: COMPLETED ·Phase: PHASE4
-
Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart Failure
NCT02917031 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Sitagliptin on Progression of Coronary Intermediate Lesion
NCT02655757 ·Status: COMPLETED ·Phase: PHASE4
-
A Study to Observe the Effectiveness of Empagliflozin, Other SGLT-2 Inhibitors, or DPP-4 Inhibitors in Patients With Type 2 Diabetes
NCT03817463 ·Status: COMPLETED
-
Sitagliptin in Prevention of Type 2 Diabetes Mellitus
NCT01038648 ·Status: WITHDRAWN ·Phase: PHASE3
-
Using of SGLt2 Inhibitors in Patients With Type 2 DM
NCT06268977 ·Status: NOT_YET_RECRUITING
-
Clinical Study on Sitagliptin for Assessment of Glucose-lowering Effects (0431-045)
NCT00758069 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Understand Usage and Effect of Saxagliptin as First Add-On After Metformin in Indian Type 2 Diabetes Mellitus Patients
NCT02588859 ·Status: COMPLETED
-
Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes
NCT00789191 ·Status: COMPLETED ·Phase: PHASE3
-
A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Sulfonylurea With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-253)
NCT01590771 ·Status: COMPLETED ·Phase: PHASE3
-
Quantification of the Dipeptidyl Peptidase (DPP)-4 Inhibition-mediated Enhancement of the Activity of the Entero-insular Axis
NCT00683735 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Study to Assess the Effects of DPP-4 Inhibition on Insulin Sensitivity in Type 2 Diabetes
NCT00351546 ·Status: COMPLETED ·Phase: PHASE3
-
Comparison of the FGM Profiles in Patients of Type 2 Diabetes Treated With Sitagliptin and Acarbose
NCT05035849 ·Status: COMPLETED ·Phase: NA