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Does Oxytocin Alter Tolerance to or Motivation for Alcohol

NCT05312008 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2025-03-04

Study results available
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Summary

This pilot study is intended to demonstrate feasibility and acquire preliminary data. If successful, this data could support a future project studying the effect of oxytocin on tolerance and alcohol seeking in humans.

Conditions

Interventions

DRUG

Intranasal oxytocin

Initial dose 40 IU in 1 ml; 2 booster doses of 24 IU in 0.6 mls each, spaced about 1 hour apart

DRUG

Intranasal placebo

Initial volume 1 ml; 2 booster volumes of 0.6 mls each, spaced about 1 hour apart

Sponsors & Collaborators

  • Indiana University

    lead OTHER

Principal Investigators

  • Martin H Plawecki, MD, PhD · Psychiatry, Indiana University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-16
Primary Completion
2023-12-21
Completion
2023-12-21
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05312008 on ClinicalTrials.gov