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Evaluation of a Novel PET Radioligand to Image OGA

NCT03632226 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2019-06-28

No results posted yet for this study

Summary

Background:

O-GlcNAcase (OGA) is a brain enzyme. It may play a role in brain disorders like Alzheimer s disease. Researchers want to see if a new drug can be used with positron emission tomography (PET) scans to show OGA better. Researchers want to learn more about how it acts in healthy people.

Objectives:

To test if the new drug \[18F\]OGA-1 can measure its receptor. To determine whether the same results occur when scanning a person twice.

Eligibility:

Healthy adults age 18 and older who are already enrolled in a separate protocol.

Design:

Some participants will have 1 whole-body PET scan during one 4-hour visit to the clinic. Some will have 2-3 brain scans (PET and MRI) over 2-3 days.

For the PET scan, a needle will guide a thin plastic tube (IV catheter) into an arm vein. A small amount of radioactive chemical will be injected through the catheter. The needle will be removed. Only the catheter will be left in the vein.

Another IV catheter may be placed to draw blood.

Blood pressure, heart rate, and breathing rate will be measured. Participants will have an electrocardiogram.

Participants will lie on a bed that slides in and out of the donut-shaped scanner.

The scan will last 2-3 hours.

For brain PET scan, participants will wear a plastic mask to keep their head still.

For magnetic resonance imaging (MRI) scan, participants will lie on a table. The table slides in and out of the MRI scanner. This is a metal cylinder in a strong magnetic field. Participants will be in the scanner up to 1 hour.

Conditions

  • Pharmacokinetics
  • Adult

Interventions

DRUG

18F-OGA-1

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    lead NIH

Principal Investigators

  • Robert B Innis, M.D. · National Institute of Mental Health (NIMH)

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-02
Primary Completion
2019-06-25
Completion
2019-06-25
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03632226 on ClinicalTrials.gov