Phase 0 Study of [18F]MNI-968 as a Marker for D1 Receptor in Healthy Subjects
NCT03082768 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 6
Last updated 2018-03-06
Summary
The overall goal of this protocol is to evaluate \[18F\]MNI-968 (aka PF-06730110) as a D1 receptor targeted radiopharmaceutical.
Conditions
- Healthy Volunteers
Interventions
- DRUG
-
[18F]MNI-968
Healthy volunteers recruited for the study will undergo two \[18F\]MNI-968 injections and PET scans.
Sponsors & Collaborators
-
Molecular NeuroImaging
lead OTHER
Principal Investigators
-
Jennifer Madonia, PA-C · Molecular NeuroImaging, LLC
Study Design
- Allocation
- NA
- Purpose
- OTHER
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2017-03-03
- Primary Completion
- 2018-03-01
- Completion
- 2018-03-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies
NCT02531360 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluation of [18F] PBR06 and PET as a Marker of Inflammation in Subjects With Neurological Conditions
NCT01028209 ·Status: TERMINATED ·Phase: PHASE1
-
Evaluation of [18F]MK-9470 as a Brain Tracer of Cannabinoid-1 Receptor in Parkinson's Disease and Healthy Subjects
NCT01462708 ·Status: COMPLETED ·Phase: PHASE1
-
A Study To Assess Effects Of PF-04958242 On Bold Functional Magnetic Resonance Imaging During Working Memory Activation And Arterial Spin Labeling At Rest In Healthy Subjects
NCT01365338 ·Status: COMPLETED ·Phase: PHASE1
-
BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006)
NCT00887601 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
NCT03080051 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
NCT02103894 ·Status: COMPLETED ·Phase: PHASE1
-
Neuromelanin MRI: A Progression Marker in Early PD
NCT05631158 ·Status: UNKNOWN
-
Functional Neuroimaging in Parkinson's Disease
NCT04904068 ·Status: COMPLETED
-
Study of Safety, Blood Levels and Brain Receptor Occupancy of GSK598809 Using PET Imaging in Health Males.
NCT00468806 ·Status: COMPLETED ·Phase: PHASE1
-
Biodistribution and Safety of a Radiopharmaceutical in Healthy Subjects
NCT00316797 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of [18F] FEPPA and PET Imaging as a Marker of Inflammation in Subjects With Neurological Conditions
NCT00970333 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of [13C]Pyruvate as an Imaging Agent for Magnetic Resonance Imaging in Healthy Volunteers
NCT05041166 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE1
-
Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
NCT04057807 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
PET Whole Body Biodistribution and Test Retest Bain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]Rolipram
NCT00250172 ·Status: COMPLETED ·Phase: PHASE1
-
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28
NCT00407693 ·Status: COMPLETED ·Phase: PHASE1
-
[18F]PI-2620 Phase 3 Histopathological Study
NCT05641688 ·Status: RECRUITING ·Phase: PHASE3
-
18F-mFBG Cardiac Uptake With Lewy Body Dementia
NCT07176286 ·Status: RECRUITING ·Phase: PHASE2
-
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
NCT06874205 ·Status: RECRUITING ·Phase: PHASE1
-
Brain Imaging Study of F17464
NCT01689038 ·Status: COMPLETED ·Phase: PHASE1
-
Normative Values for Cognitive Testing and Alzheimer's Imaging Biomarkers in Young Adults
NCT01609335 ·Status: COMPLETED ·Phase: PHASE1
-
Optimization and Harmonization of Advanced MRI Sequences
NCT06217237 ·Status: COMPLETED
-
Investigation of Brain Nitrogen in Partial Ornithine Transcarbamylase Deficiency (OTCD) Using 1 H MRS, DTI, and fMRI
NCT01569568 ·Status: COMPLETED
-
Establishing 18F-PBR06 PET Imaging as a Viable Pharmacodynamic Endpoint in MSA
NCT03033680 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Beta-Amyloid Imaging With [18F]NAV4694 PET in Predicting Progression to AD in Subjects MCI
NCT01812213 ·Status: TERMINATED ·Phase: PHASE2