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Pathogenesis of Compromised Bone Quality and Mechanics in Chronic Kidney Disease

NCT03626246 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2021-07-13

No results posted yet for this study

Summary

Kidney disease patients have a variety of bone disorders that result in bone loss and fractures. The mechanisms of these bone disorders are not clear but may be related to abnormal modification of a bone protein known as collagen. Therefore, the investigators are conducting this research study to identify underlying mechanisms that are responsible for the disruption of bone collagen and determining whether the abnormal bone collagen impairs bone strength. The investigators intend to identify these mechanisms through studying relationships between kidney disease and bone strength via bone imaging, bone biopsy and non-invasive measures from blood and skin.

Conditions

Interventions

OTHER

Kidney disease

Being part of this study you agree to participate in all these interventions: Genetic: • Blood sample Procedure/Surgery: • Bone and muscle biopsies. Radiation: * Bone density (DXA) * Thoracic and lumbar spine plain films. * HRpQCT: high-resolution peripheral quantitative computed tomography Other: * Completing medical history, physical activity level, and dietary questionnaires for calcium and vitamin D. * Measure levels of Advanced Glycation End products (AGEs) in the skin.

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Thomas Nickolas, MD,MS · Columbia University

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-07-01
Primary Completion
2020-02-28
Completion
2020-02-28

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03626246 on ClinicalTrials.gov