End stage kidney disease (ESKD) is kidney failure requiring kidney replacement therapy, typically chronic dialysis or kidney transplantation. It represents the most advanced stage of chronic kidney disease with severe loss of renal function and high morbidity. ESKD is also referred to as end-stage renal disease (ESRD).
Eli Lilly has acquired rights to CSL's IL-6 inhibitor clazakizumab in a $100 million deal, expanding its cardiometabolic pipeline. The monoclonal antibody targets chronic inflammation, particularly in cardiovascular conditions. This move follows Lilly's successful obesity and diabetes drugs that drove $65.1 billion in 2025 revenue.
New studies show SGLT2 inhibitors and GLP-1 receptor agonists reduce risks of kidney failure, cardiovascular events, and liver complications in patients with type 2 diabetes, with particularly strong benefits in those with cirrhosis.
CSL Limited has licensed global development and commercialization rights for clazakizumab to Eli Lilly outside of ESKD-related cardiovascular risk. CSL receives $100 million upfront and retains rights to the ESKD indication.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07426380 |
A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function |
RECRUITING | PHASE1 |
| NCT07051447 |
The Reducing Adverse Outcomes in Dialysis by Adjusting the pRescription for Dialysate Potassium Trial |
NOT_YET_RECRUITING | NA |
| NCT06613568 |
Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants |
RECRUITING | NA |
| NCT06581393 |
First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings |
COMPLETED | NA |
| NCT06356168 |
Virtual Reality in End Stage Kidney Disease |
RECRUITING | NA |
| NCT06056739 |
Alio WEAR Study: Long-term Wear of the Alio Platform |
RECRUITING | NA |
| NCT05836220 |
Parathyroid Hormone (PTH) Attenuation Trial in Hemodialysis-2 |
COMPLETED | PHASE3 |
| NCT05806749 |
Immunological Tolerance in Patients With Mismatched Kidney Transplants |
ACTIVE_NOT_RECRUITING | PHASE1 |
| NCT05774392 |
An Observational Study of Patients With Chronic Kidney Disease |
WITHDRAWN | |
| NCT05741489 |
Continuous Glucose Monitoring in Patients With End-Stage Kidney Disease and Burnt-Out Diabetes |
COMPLETED | NA |
