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The Risk of Adrenal Insufficiency and Cushing Syndrome Associated With Glucocorticoid Therapy in People With Chronic Inflammatory Diseases

NCT03575247 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 111804

Last updated 2018-07-02

No results posted yet for this study

Summary

Glucocorticoids are widely used for the treatment of chronic inflammatory diseases. Although glucocorticoids are effective in controlling disease symptoms, continuous use of the drugs can lead to suppression of adrenal hormones or excessive cortisol level in the blood stream. That is, excess blood cortisol level due to glucocorticoid exogenous supply can either inhibit the 'hypothalamus-pituitary-adrenal axis' for adrenal hormones production or result in Cushing symptoms.

In the period between 1989 and 2008 in the UK, it was estimated that 0.6%-0.8% of the general adult population were long-term users of oral glucocorticoids. However, there is no data on the risk of adrenal suppression and Cushing syndrome due to chronic use of glucocorticoids in the UK to date.

The aim of the study is to investigate the risk of adrenal insufficiency and Cushing syndrome due to long-term use of glucocorticoids in England.

Conditions

  • Adrenal; Insufficiency Gluccorticoid-Induced
  • Cushing; Syndrome or Disease, Glucocorticoid-Induced

Interventions

DRUG

Glucocorticoids

Long-term use of glucocorticoids

Sponsors & Collaborators

  • University of Leeds

    lead OTHER

Principal Investigators

  • Mar Pujades-Rodriguez, PhD · University of Leeds

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1998-01-01
Primary Completion
2015-01-30
Completion
2015-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03575247 on ClinicalTrials.gov