MedTrace Logo

The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids in Patients With Corticotropic Hypopituitarism

NCT02360046 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2018-10-09

No results posted yet for this study

Summary

This study aims at assessing the effect of today's standard of hydrocortisone dosage versus previous hydrocortisone dosage on flexibility and partitioning of ectopic lipid depots (IMCL and IHCL) after a standardised fat load followed by a short-term aerobic exercise in patients with corticotropic pituitary insufficiency.

Conditions

  • Hypopituitarism
  • Hydrocortisone
  • Lipids
  • Fatty Acids, Nonesterified
  • Insulin Sensitivity

Interventions

DRUG

Hydrocortisone

Established Hydrocortisone replacement therapy plus Hydrocortisone (10mg/day)

DRUG

Placebo

Established Hydrocortisone replacement therapy plus Placebo (0mg Hydrocortisone)

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Emanuel Christ, MD, PhD · Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern

  • Chris Boesch, MD, PhD · AMSM; Division of Radiology, University Hopsital of Bern, Inselspital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02360046 on ClinicalTrials.gov