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The CLiFF Study: Change in Liver Function and Fat in Pre-operative Chemotherapy for Colorectal Liver Metastases

NCT03562234 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2018-11-07

No results posted yet for this study

Summary

The CLiFF Study will assess changes in liver function and liver fat in patients with colorectal liver metastases (CLM) undergoing pre-operative chemotherapy before liver resection. There will be no change to the standard treatment for CLM. The change in liver fat will be assessed using novel magnetic resonance techniques and the change in liver function will be measured using a newly-developed fully-licensed breath test to give the most accurate measure of liver function possible.

Understanding if these changes are related or reversible will help to understand the relationship between obesity and cancer. This is an important issue, as obesity is now the second most common cause of cancer worldwide.

Conditions

Interventions

DIAGNOSTIC_TEST

MR

Liver fat (measured as a percentage - hepatic fat fraction) will be measured by Magnetic Resonance imaging

DIAGNOSTIC_TEST

LiMAx

Liver function will be measured using the relatively new CE licenced non-invasive LiMAx (Liver Maximum Capacity) test device, manufactured by Humedics GmbH

Sponsors & Collaborators

  • The Christie NHS Foundation Trust

    collaborator OTHER

  • Manchester University NHS Foundation Trust

    collaborator OTHER_GOV

  • National Institute for Health Research, United Kingdom

    collaborator OTHER_GOV

  • National Health Service, United Kingdom

    collaborator OTHER_GOV

  • Humedics GmbH

    collaborator INDUSTRY

  • University of Manchester

    lead OTHER

Principal Investigators

  • Prof A G Renehan, PhD FRCS · The Christie NHS Foundation Trust, The University of Manchester

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-10-22
Primary Completion
2020-02-29
Completion
2020-04-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03562234 on ClinicalTrials.gov