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Iowa Fluoride Study/Iowa Bone Development Study

NCT03547128 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1882

Last updated 2025-02-25

No results posted yet for this study

Summary

A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at \~ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.

Conditions

  • Dental Caries
  • Dental Fluoroses
  • Bone Density

Sponsors & Collaborators

  • Steven M Levy

    lead OTHER

Principal Investigators

  • Steven M Levy, dds · University of Iowa

Eligibility

Min Age
1 Month
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1992-03-01
Primary Completion
1996-03-01
Completion
2019-06-18

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03547128 on ClinicalTrials.gov