A Study of Gemcitabine, Nab-paclitaxel, Capecitabine, Cisplatin, and Irinotecan in Metastatic Pancreatic Cancer
NCT03535727 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2024-12-31
Summary
The purpose of this study is to evaluate the clinical activity of gemcitabine, nab-paclitaxel, capecitabine, cisplatin, and irinotecan (GAX-CI) in patients with metastatic pancreatic cancer.
Conditions
- Adenocarcinoma
- Pancreatic Neoplasms
- Neoplasm, Glandular
- Neoplasms
- Neoplasms Pancreatic
- Digestive System Neoplasm
- Endocrine Gland Neoplasms
- Digestive System Disease
- Pancreatic Diseases
- Endocrine System Diseases
Interventions
- DRUG
-
IV over 30 minutes; Days 1 and 15
- DRUG
-
IV over 30 minutes; Days 1 and 15
- DRUG
-
PO twice daily (BID); Days 1-7, 15-21
- DRUG
-
IV over 60 minutes; Days 1 and 15
- DRUG
-
IV over 30 minutes; Days 1 and 15
- DRUG
-
IV over 30 minutes; Days 4 and 11
- DRUG
-
IV over 30 minutes; Days 4 and 11
- DRUG
-
PO BID; Days 1- 14
- DRUG
-
IV over 60 minutes; Days 4 and 11
- DRUG
-
IV over 30 minutes; Days 4 and 11
Sponsors & Collaborators
-
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
lead OTHER
Principal Investigators
-
Dung Le, MD · Johns Hopkins Medical Institution
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 76 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-06-21
- Primary Completion
- 2022-10-03
- Completion
- 2022-10-03
- FDA Drug
- Yes
Countries
- United States
Study Locations
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