Frailty and Sarcopenia Outcomes in Emergency General Surgery

Summary

1. A retrospective scoping cohort review of adult patients undergoing emergency laparotomy/laparoscopy for acute gastrointestinal (GI) pathology who have had a CT scan of the abdomen(+/- pelvis). CT measured sarcopenia would be compared with clinical outcomes, 30-day and 1-year mortality.
2. A prospective observational cohort study and bio-banking exercise of routinely collected clinical data, in a cohort of patient undergoing emergency laparotomy/laparoscopy or conservative treatment for an otherwise operable pathology. An interrogation of CT measured sarcopenia and a validated clinical frailty score would be analysed against clinical outcomes, 30-day and 1-year mortality.

The investigators aim to research the association and predictive advantage of combining subjectively measured frailty, objectively measured CT sarcopenia and other risk predicting tools used in every day surgical practice and surgical outcomes (mortality and morbidity) in a cohort of acute surgical patients undergoing surgery or conservative treatment.

Conditions

• Frail Elderly Syndrome
• Emergencies
• Surgery
• Sarcopenia

Interventions

DIAGNOSTIC_TEST

CT abdomen +/- pelvis

Diagnostic CT scan (only if requested by responsible clinicians)

DIAGNOSTIC_TEST

Edmunton Frailty Score

Patient completed previously valided questionnaire quantifying frailty.

PROCEDURE

Emergency laparotomy for general surgical pathology

Emergency general surgical laparotomy (defined by the UK NELA body)

Sponsors & Collaborators

• University Hospital Southampton NHS Foundation Trust

  collaborator OTHER

• Basingstoke and North Hampshire Hospital

  collaborator UNKNOWN

• Dorset County Hospital NHS Foundation Trust

  collaborator OTHER_GOV

• Poole Hospital NHS Foundation Trust

  collaborator OTHER

• Portsmouth Hospitals NHS Trust

  collaborator OTHER_GOV

• Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust

  collaborator OTHER_GOV

• Salisbury NHS Foundation Trust

  collaborator OTHER_GOV

• University of Southampton

  collaborator OTHER

• National Institute for Health Research, United Kingdom

  collaborator OTHER_GOV

• Hampshire Hospitals NHS Foundation Trust

  collaborator OTHER

• Isle of Wight NHS Trust

  collaborator OTHER

• Yeovil District Hospital NHS Foundation Trust

  lead OTHER

Principal Investigators

• Malcolm West, MD PhD MRCS · University of Southampton

Eligibility

Min Age

18 Years

Max Age

100 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-10-01

Primary Completion

2019-03-31

Completion

2020-08-01

Countries

• United Kingdom

Study Locations