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Clinical and Histomorphometric Analysis of Collagen Matrix Versus Connective Tissue Graft in Mucogingival Surgery in Orthodontic Patients

NCT03533933 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 5

Last updated 2019-07-23

No results posted yet for this study

Summary

There are some orthodontics treatments that perform risk movements ,and a bone dehiscence may be expected. In that cases mucogingival surgery , such as connective tissue grafts, is necessary prior to tooth movement.

The connective tissue graft in combination with coronal advanced flap is still considered the gold standard , although the use of porcine collagen matrix has obtained promising results for treatment of Miller class I and II recession defects.

Most of the studies report clinical results after a connective tissue graft and there is no evidence about the type of attachment obtained after the graft is performed, a few articles have shown histological results. But, as a rule , a histological study is only performed under exceptional circumstances such as a dental fracture, untreatable decay, tooth extraction for orthodontic reasons, or other reasons.

Most of the techniques results in the formation of a long junctional epithelium and connective tissue attachment with fibers parallel to the root surface. Animals studies have shown a shorter epithelium and a larger new cementum formation after the use of the collagen matrix.

Conditions

  • Gingival Recession

Interventions

DEVICE

Collagen matrix

Mucograft collagen matrix combined with coronal advanced flap

OTHER

autologous connective tissue graft

Soft tissue harvesting from patient palate with coronal advanced flap

Sponsors & Collaborators

  • Elena Ruiz de Gopegui Palacios

    lead OTHER

Principal Investigators

  • Luis Antonio Aguirre Zorzano · University of the Basque Country (UPV/EHU)

  • Elena Ruiz de Gopegui · University of the Basque Country (UPV/EHU)

  • Ana Maria Garcia de la Fuente · University of the Basque Country (UPV/EHU)

  • Ruth Estefania Fresco · University of the Basque Country (UPV/EHU)

  • Xavier Marichalar Mendia · University of the Basque Country (UPV/EHU)

  • Jose Manuel Aguirre Urizar · University of the Basque Country (UPV/EHU)

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2021-06-01
Completion
2022-06-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03533933 on ClinicalTrials.gov