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Endoscopy and Endomicroscopy for Assessment of Mucosal Healing in Inflammatory Bowel Disease (IBD)

NCT01524120 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2020-12-14

No results posted yet for this study

Summary

Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC). Diagnosis is based on several macroscopic and histologic features including patterns of inflammation, crypt abscesses and granulomas. Confocal laser endomicroscopy (CLE) is rapidly emerging as a valuable tool for gastrointestinal endoscopic imaging, enabling the endoscopist to obtain an "optical biopsy" of the gastrointestinal mucosa during the endoscopic procedure.

The main objective of this study is to determine endoscopic and endomicroscopic features of mucosal healing in patients with IBD.

Conditions

Interventions

DEVICE

Endoscopy (EPK-i, Pentax, Tokyo, Japan)

Patients will undergo white-light endoscopy. Any mucosal lesions will be recorded and findings will be compared to histopathological and clinical results.

DEVICE

Endomicroscopy (iCLE, Pentax, Tokyo, Japan)

Patients will undergo endomicroscopy. Data will be recorded and findings will be compared to histopathological and clinical results.

DEVICE

Endoscopy (EPK-i, Pentax, Tokyo, Japan)

Patients will undergo white-light endoscopy. Any mucosal lesions will be recorded and findings will be compared to histopathological and clinical results.

DEVICE

Endomicroscopy (iCLE, Pentax, Tokyo, Japan)

Patients will undergo endomicroscopy. Data will be recorded and findings will be compared to histopathological and clinical results.

Sponsors & Collaborators

  • University of Erlangen-Nürnberg Medical School

    lead OTHER

Principal Investigators

  • Markus F. Neurath, M.D., Ph.D. · University of Erlangen-Nürnberg

  • Helmut Neumann, M.D., Ph.D. · University of Erlangen-Nürnberg

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-04-30

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01524120 on ClinicalTrials.gov