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Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

NCT03520569 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2022-05-13

Study results available
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Summary

The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults

Conditions

  • Vascular Stiffness
  • Insulin Sensitivity

Interventions

DRUG

Octreotide

we are using it to block insulin secretion from the pancreas

DRUG

Insulin

we are using to replace basal insulin and in two protocols to raise insulin concentrations during the insulin clamp

DRUG

Dextrose 20% solution

We are using dextrose to maintain glycemia level

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • University of Virginia

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-02-04
Primary Completion
2021-04-01
Completion
2021-04-01
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03520569 on ClinicalTrials.gov