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Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease

NCT03476785 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 56

Last updated 2019-10-14

No results posted yet for this study

Summary

The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart failure will improve cardiac and vascular compliance to a degree equivalent to life-long exercisers and the sedentary young. To date, no effective therapy for heart failure with preserved ejection fraction (HFpEF) has been found; therefore prevention is critical and discovering novel treatment strategies is essential. Exercise training if implemented in high risk patients may improve diastolic function and cardiac-vascular interactions, preventing further progression to overt heart failure.

Conditions

  • Lv Hypertrophy
  • Heart Failure, Diastolic
  • Stiffness, Vascular

Interventions

BEHAVIORAL

High intensity exercise

Subjects will perform high intensity aerobic exercise in addition to moderate intensity sessions 4-5 times per week.

BEHAVIORAL

Yoga

Subjects will perform strength and flexibility exercises.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Principal Investigators

  • Benjamin D Levine, MD · University of Texas Southwestern Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-01
Primary Completion
2019-07-02
Completion
2019-07-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03476785 on ClinicalTrials.gov