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Serum Granulysin Level as a Marker to Detect the Severity of Psoriasis

NCT03469219 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2018-03-23

No results posted yet for this study

Summary

Psoriasis is a chronic inflammatory and proliferative papulosquamous skin disease of unknown cause,overexpression of Anti Microbial Peptides is characteristic of psoriasis.

Granulysin is a cytolytic and proinflammatory peptide that belongs to a family of saposin-like, lipid binding antimicrobial peptides, and localized in the granular compartments of cytotoxic T lymphocytes and natural killer cells,Patients with psoriasis had high tissue granulysin expression, which increased with increased clinical severity of the disease.

The aim of the study is to measure serum granulysin level and correlate with severity of psoriasis and tissue level of granulysin.

Conditions

  • Psoriasis Vulgaris

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Hisham Diab, assis prof · Assiut University

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-07-31
Primary Completion
2018-12-31
Completion
2019-03-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03469219 on ClinicalTrials.gov