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Gut Microbiome and Serum Metabolome Alterations in ADHD Patients

NCT03447223 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 207

Last updated 2021-08-27

No results posted yet for this study

Summary

Host-microbe interactions play a key role in brain development and function and in the etiology of neurodevelopmental disorders. Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder that affects 1 in 20 children and results in poor life-time outcomes. However, the etiology of ADHD is unclear and its diagnosis and treatment are still challenging. Different factors reported to be associated with the risk of developing ADHD and/or linked to different ADHD manifestations have also been linked to shifts in gut microbiota composition, suggesting a link between the microbiota and the disorder. Here, we will perform a metagenome-wide association study and serum metabolomics profiling in a cohort of control and ADHD, 6-15 years, Chinese individuals. We aim to identify ADHD-associated gut microbial species linked to changes in circulating metabolites. We also aim to find the possible intervention strategy in ADHD by targeting the gut microbiota.

Conditions

  • Attention-deficit/Hyperactivity Disorder

Sponsors & Collaborators

  • Xijing Hospital

    lead OTHER

Principal Investigators

  • Lize Xiong, M.D./Ph.D. · Professor and President, Xijing Hospital

Eligibility

Min Age
6 Years
Max Age
15 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-20
Primary Completion
2020-02-27
Completion
2020-05-27

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03447223 on ClinicalTrials.gov