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Albumin Mass Balance in Liver Transplantation

NCT03441035 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2020-09-03

No results posted yet for this study

Summary

This clinical observational cohort study assess the loss of albumin from blood circulation during and after liver transplantation by mass balance of albumin. The overall assumption of this method is that if albumin is more diluted than hemoglobin, it must have left the plasma, presumably into the interstitial space. Predictors of albumin leakage will be assessed, including biomarkers of inflammation and of endothelial damage and dysfunction. The sub cohorts children and patients with complications, defined as prolonged postoperative treatment in the intensive care unit, respectively, will be focused in separate publications.

Conditions

  • Liver Transplant; Complications
  • Fluid Overload

Interventions

OTHER

General anesthesia and surgery (liver transplantation)

The effects of general anesthesia and surgery under the hospital routine of albumin administration during and after liver transplantation is studied with the mass balance of albumin method.

Sponsors & Collaborators

  • Ake Norberg

    lead OTHER

Principal Investigators

  • Åke Norberg, Ass Prof · Perioperative Medicine and Intensive Care, Karolinska University Hospital Huddinge

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-27
Primary Completion
2021-02-28
Completion
2021-06-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03441035 on ClinicalTrials.gov