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Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury

NCT06349577 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1100

Last updated 2025-05-21

No results posted yet for this study

Summary

The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.

Conditions

Interventions

OTHER

Non-pulsatile blood flow

Non-pulsatile blood flow generated by constant centrifugal pump flow rate during cardiopulmonary bypass

OTHER

Pulsatile blood flow

Pulsatile blood flow generated by variable centrifugal pump flow rate during cardiopulmonary bypass

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Colorado, Denver

    lead OTHER

Principal Investigators

  • Nathan J Clendenen, MD, MS · University of Colorado, Denver

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-19
Primary Completion
2028-04-30
Completion
2028-10-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06349577 on ClinicalTrials.gov