MedTrace Logo

Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections

NCT03408457 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2019-05-30

No results posted yet for this study

Summary

This study evaluates antibiotic serum concentrations in correlation with perioperative fluid balance. Patients will be recruited in rectum and esophageal surgery (representative for low blood loss and restrictive fluid management) and in liver surgery (representative for high blood loss and liberal fluid management). The hypothesis is that high blood loss and liberal fluid management dilute antibiotic serum concentrations thereby potentially increasing surgical site infections.

Conditions

  • Antibiotic
  • Anti-Bacterial Agents
  • Surgical Wound Infection

Interventions

PROCEDURE

Blood sampling after antibiotic administration

Sampling of 6 x 8 mL (in sum 48 mL) via the central venous line (established for the surgical procedure) until postoperative day 2

Sponsors & Collaborators

  • Johannes Gutenberg University Mainz

    lead OTHER

Principal Investigators

  • Serge C Thal, MD PhD · University Medical Center of the Johannes Gutenberg-University Mainz

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-14
Primary Completion
2019-04-04
Completion
2019-05-14

Countries

  • Germany

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03408457 on ClinicalTrials.gov