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Optimal VAsopressor TitraTION in Patients 65 Years and Older

NCT03431181 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 159

Last updated 2024-05-16

No results posted yet for this study

Summary

We have designed OVATION-65 to evaluate the effects of permissive low blood pressure compared to usual care on markers of organ injury and survival in older patients.

Conditions

  • Vasopressors
  • Hypotension
  • Mean Arterial Pressure Targets
  • Usual Care

Interventions

BEHAVIORAL

MAP target 60-65 mmHg

Treating teams will adjust vasopressors to a target MAP range of 60 to 65 mmHg, avoiding vasopressor-induced MAP above this range.

BEHAVIORAL

Usual care

Patients in the control arm will receive usual care (as per local practices).

Sponsors & Collaborators

  • Université de Sherbrooke

    lead OTHER

Principal Investigators

  • François Lamontagne, MD FRCPC MSc · University of Sherbrooke and CIUSSS de l'Estrie-CHUS

  • Neill Adhikari, MDCM MSc · Sunnybrook Health Sciences Centre, University of Toronto

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-02-16
Primary Completion
2020-02-21
Completion
2024-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03431181 on ClinicalTrials.gov