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HIV Persistence in Lymph Node and Peripheral Blood

NCT03426189 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 8

Last updated 2021-06-23

No results posted yet for this study

Summary

The aim of this project is to determine whether latent HIV is enriched in cells expressing certain proteins (receptors) on their surface and whether it is possible to eliminate these cells through the use of drugs that specifically target these proteins. Lymph nodes are known to contain very high numbers of HIV infected cells.

Conditions

Interventions

PROCEDURE

Leukapheresis

Blood will be taken by a needle inserted into a vein in one arm and processed through a machine, which spins the blood so that the white blood cells will be separated out of the machine for purposes of this research. The rest of the blood will be returned through a needle in the other arm.

PROCEDURE

Lymph node biopsy

Ultrasound will be used to localize the position of one lymph node in the groin. Under a light general anesthetic, one lymph node will be removed.

Sponsors & Collaborators

Principal Investigators

  • Sharon Lewin · The Peter Doherty Institute for Infection and Immunity, University of Melbourne

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-02
Primary Completion
2018-10-17
Completion
2018-10-17

Countries

  • Australia

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03426189 on ClinicalTrials.gov