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Ethnic/Racial Differences in Metabolism and DNA Adduct Formation

NCT03421678 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2020-10-05

No results posted yet for this study

Summary

The study will investigate the role of 1,3-butadiene metabolic activation and deactivation in lung cancer risk among various ethnic/racial groups. This project will require urine samples from smokers and nonsmokers from the three ethnic/racial groups recruited by the Clinical and Biomarker Core for the analysis of 1,3-butadiene DNA adducts. Data on nicotine intake (urinary TNE) in these subjects as well as in 400 lung cancer cases and 400 controls from Project 1 will be also required for this project.

Conditions

Interventions

DIAGNOSTIC_TEST

Urine Sample

One to two home visits where tobacco use and medical history and biological samples will be collected including blood, buccal cells and urine

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Masonic Cancer Center, University of Minnesota

    lead OTHER

Principal Investigators

  • Dorothy Hatsukami, Ph.D. · University of Minnesota, Department of Psychiatry

Eligibility

Min Age
21 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-10-31
Primary Completion
2023-06-30
Completion
2023-06-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03421678 on ClinicalTrials.gov