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Proteomic Analysis of Crohn's Disease Macrophages in Response or Not to AIEC

NCT03404557 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 88

Last updated 2019-02-04

No results posted yet for this study

Summary

The M2iSH laboratory showed with two previous clinical trials that Crohn's Disease (CD) macrophages present i) a defect to control Adherent-Invasive Escherichia coli (AIEC) infection related to polymorphisms associated with CD; ii) a CD - specific cytokine secretion profile after an AIEC infection and intestinal inflammation dependent; iii) a modification of the response of CD macrophages at a basal state and after the AIEC infection. These results consolidate the hypothesis of a defect specific to CD macrophages.

That's why, the primary purpose of this study is to realize a proteomic analysis of macrophages of CD patients infected or not with AIEC and to compare them to Ulcerative Colitis (UC) patients and healthy volunteers.

Conditions

Interventions

OTHER

Proteomic analysis

Proteomic analysis of Crohn's disease macrophages in response or not to Adherent-Invasive Escherichia coli

Sponsors & Collaborators

  • Laboratoire M2Ish

    collaborator UNKNOWN

  • University Hospital, Clermont-Ferrand

    lead OTHER

Principal Investigators

  • Anthony BUISSON · University Hospital, Clermont-Ferrand

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-01-18
Primary Completion
2019-01-18
Completion
2019-01-18

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03404557 on ClinicalTrials.gov