Insulin Deprivation on Brain Structure and Function in Humans With Type 1 Diabetes
NCT03392441 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 28
Last updated 2022-02-03
Summary
What are the effects of transient insulin deprivation on brain structure, blood flow, mitochondrial function, and cognitive function in T1DM patients?
What are the effects of transient insulin deprivation on circulating exosomes and metabolites in T1DM patients?
Conditions
- Diabetes Mellitus, Type 1
- Diabetes
- Diabetes Complications
Interventions
- OTHER
-
Insulin Deprivation in Type 1 Diabetic Patients
Type 1 Diabetic Patients requiring insulin will have insulin stopped for a short period of time (4-6 hours)
Sponsors & Collaborators
- lead OTHER
Principal Investigators
-
K Sreekumaran Nair · Mayo Clinic
Study Design
- Allocation
- NA
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 14 Years
- Max Age
- 45 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2017-11-30
- Primary Completion
- 2018-08-01
- Completion
- 2019-07-05
Countries
- United States
Study Locations
More Related Trials
-
Influence of Central Nervous Insulin Action on Insulin Sensitivity of Peripheral Organs in Lean Versus Overweight Humans
NCT02468999 ·Status: COMPLETED ·Phase: NA
-
Improving Insulin Sensitivity by Non-invasive Brain Stimulation in Persons With Insulin Resistance
NCT04052399 ·Status: UNKNOWN ·Phase: NA
-
Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
NCT01206322 ·Status: COMPLETED ·Phase: PHASE2
-
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
NCT05985135 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet
NCT00118937 ·Status: COMPLETED ·Phase: PHASE4
-
Effects of Metreleptin in Type 1 Diabetes Mellitus
NCT01268644 ·Status: TERMINATED ·Phase: PHASE1
-
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
NCT04133922 ·Status: WITHDRAWN ·Phase: EARLY_PHASE1
-
A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes
NCT04118374 ·Status: COMPLETED ·Phase: NA
-
Ketone Monitoring in T1D: Effect of SGLT2i During Usual Care and With Insulin Deficiency
NCT05541484 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of a Ketogenic Diet in Type 1 Diabetes
NCT06503809 ·Status: RECRUITING ·Phase: NA
-
Effect of GLP-1 on Glucose Metabolism in CNS Assessed by PET
NCT01185119 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
The Role of Endogenous Glucagon-like Peptide 1 (GLP-1) in Type 2 Diabetes Mellitus (T2DM)
NCT01449019 ·Status: COMPLETED ·Phase: PHASE1
-
Effects of Age and Obesity on Brain Insulin Sensitivity
NCT04372849 ·Status: COMPLETED ·Phase: NA
-
The Effect of GLP-1 on Glucose Uptake in the Brain and Heart in Healthy Men During Hypoglycemia
NCT00418288 ·Status: COMPLETED ·Phase: NA
-
The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism
NCT01479075 ·Status: COMPLETED ·Phase: PHASE4
-
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
NCT06967558 ·Status: RECRUITING ·Phase: PHASE2
-
Incretin Hormones in Type-1 Diabetes Mellitus Glycemic Response in Type-1 Diabetes Mellitus
NCT00832741 ·Status: COMPLETED
-
Importance in Type 1 Diabetes Patients of an Optimized Control of Post-Prandial Glycaemia on Oxidant Stress Prevention
NCT00934336 ·Status: COMPLETED ·Phase: NA
-
Carnitine Levels and Carnitine Supplementation in Type I Diabetes
NCT00351234 ·Status: COMPLETED
-
Sleep Apnea in Type 1 Diabetes
NCT01935765 ·Status: COMPLETED ·Phase: NA
-
Central Insulin Sensitivity in Individuals With Type 2 Diabetes (T2D) and at Risk for Developing T2D
NCT05856877 ·Status: RECRUITING ·Phase: NA
-
GLP-1 and Hypoglycemia
NCT01858896 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Endogenous GLP-1 Secretion on Islet Function in People With and Without Type 2 Diabetes
NCT04466618 ·Status: COMPLETED ·Phase: PHASE3
-
Postprandial Blood Glucose Control and Gastric Emptying in Type 1 Diabetes: Pathogenetic Factors and Therapeutic Options
NCT02365740 ·Status: UNKNOWN ·Phase: NA
-
Eating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy
NCT07151924 ·Status: ACTIVE_NOT_RECRUITING