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Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis

NCT03391414 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2018-01-05

No results posted yet for this study

Summary

This study will compare the use of inhaled concentrated sodium chloride solution to an inhaled solution of sodium bicarbonate in an attempt to decrease the thickness and stickiness of the mucus in the lungs of a person with cystic fibrosis. Also, this study is also looking at whether or not it is possible to decrease the acidity of the airways by inhaling sodium bicarbonate through nebulizer treatments.

Conditions

Interventions

DRUG

hypertonic bicarbonate

8.4% sodium bicarbonate inhaled

DRUG

sodium chloride

7% sodium chloride inhaled

Sponsors & Collaborators

  • Cystic Fibrosis Foundation

    collaborator OTHER

  • Joseph Pilewski

    lead OTHER

Principal Investigators

  • Joseph M PIlewski, MD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-08-31
Primary Completion
2016-07-31
Completion
2016-07-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03391414 on ClinicalTrials.gov