Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis

Summary

Our aims were to determine if exhaled breath condensate (EBC) could detect differences in ion regulation between cystic fibrosis (CF) and healthy and measure the effect of the albuterol on EBC ions in these populations. We hypothesized EBC chloride and sodium would be lower in CF patients at baseline and that albuterol would decrease EBC sodium and increase EBC chloride.

Conditions

• Cystic Fibrosis
• Healthy

Interventions

DRUG

Albuterol

2.5 mg diluted in 3mL normal saline nebulized using a Power Neb2 nebulizer

DRUG

Placebo saline

nebulized 3mL normal saline) using a Power Neb2 nebulizer

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• University of Arizona

  lead OTHER

Principal Investigators

• Wayne J Morgan, MD · Department of Pediatrics- Pulmonology, Allergy and Immunology, University of Arizona, Tucson, Arizona

• Cori M Daines, MD · Department of Pediatrics- Pulmonology, Allergy and Immunology, University of Arizona, Tucson, Arizona

• Eric M Snyder, PhD · Department of Pharmacy Practice and Science, University of Arizona, Tucson, Arizona

• Hanna Phan, PharmD · Department of Pharmacy Practice and Science, University of Arizona, Tucson, Arizona

• Asad Patanwalla, PharmD · Department of Pharmacy Practice and Science, University of Arizona, Tucson, Arizona

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

15 Years

Max Age

55 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2009-05-31

Primary Completion

2012-07-31

Completion

2013-01-31

Countries

• United States

Study Locations