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Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

NCT03367598 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 503

Last updated 2017-12-08

No results posted yet for this study

Summary

The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Conditions

  • Overweight and Obesity

Interventions

GENETIC

rs662799 (APOA5 -1131T>C)

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism.

Sponsors & Collaborators

  • Yonsei University

    lead OTHER

Principal Investigators

  • Jong Ho Lee, PhD · Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2008-01-01
Primary Completion
2013-12-01
Completion
2013-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03367598 on ClinicalTrials.gov