Antigen-specific T Cells Against Lung Cancer
NCT03356808 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2019-09-19
Summary
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of cancer antigen-specific T cells targeting lung cancer. The cancer targeting antigens are identified through immunostaining of patient's cancer specimens. Another goal of the study is to learn more about the persistence and function of the ex vivo manipulated antigen-specific T cells in the body.
Conditions
Interventions
- BIOLOGICAL
-
Lung cancer-specific T cells
1 infusion, for 1x10\^6\~1x10\^7 cells/kg via IV
Sponsors & Collaborators
-
Shenzhen Geno-Immune Medical Institute
lead OTHER
Principal Investigators
-
Lung-Ji Chang, PhD · Shenzhen Geno-Immune Medical Institute
-
Qichun Cai, MD · Jinshazhou Hospital of Guangzhou University of Chinese Medicine
-
Xun Lai, MD · Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-12-15
- Primary Completion
- 2020-01-01
- Completion
- 2020-12-31
Countries
- China
Study Locations
More Related Trials
-
The Predicted Potential of Quantitative T Cell Repertoire(TCR) in Anti-PD-L1 Treatment in NSCLC Patients
NCT03228368 ·Status: UNKNOWN
-
Anti-PD-1 in Combination With Chemotherapy as First-Line Treatment to Lung Cancer
NCT03432598 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical Trial of Kanglaite Injection (KLTi) in Advanced Non-Small Cell Lung Cancer (NSCLC)
NCT03986528 ·Status: UNKNOWN ·Phase: PHASE4
-
A Study of GNC-077 in Patients With Locally Advanced or Metastatic Non-small-cell Lung Cancer and Other Solid Tumors
NCT06612840 ·Status: RECRUITING ·Phase: PHASE1
-
Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas
NCT03356782 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study Evaluating Neoadjuvant Chemotherapy, Concurrent Chemoradiotherapy Combined With Dual Immune Checkpoint Blockade in Patients With Locally Advanced Non-Small Cell Lung Cancer
NCT07103395 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Chemotherapy Combination With Autologous Cytokine-Induced Killer Cell Immunotherapy to Treat Lung Cancer
NCT01631357 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Study of Combinations of D-CIK Immunotherapy And Anti-PD-1 In Refractory Solid Tumors
NCT02886897 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Neoantigen-primed DC Vaccines Therapy for Refractory Lung Cancer
NCT03871205 ·Status: UNKNOWN ·Phase: PHASE1
-
Study of Autologous Cytotoxic T Lymphocyte Immunotherapy Combination With PD-1 Inhibitor in the Advanced NSCLC
NCT04193098 ·Status: UNKNOWN ·Phase: PHASE1
-
Preoperative Neoadjuvant Immunotherapy Combined With Chemotherapy for Stage Ⅲ Unresectable Non-small Cell Lung Cancer
NCT06357598 ·Status: RECRUITING ·Phase: PHASE4
-
Anti-CEA CAR-T for Advanced CEA-Positive Lung Carcinoma
NCT06903117 ·Status: RECRUITING ·Phase: PHASE1
-
COVID-19 Vaccine Effectiveness Against Recurrent Infection Among Lung Cancer Patients and Biomarker Research
NCT06168032 ·Status: RECRUITING ·Phase: NA
-
Trial of Tumor Vaccine Used for Adjuvant Therapy in Post Radical Operation Patients With Lung Cancer
NCT03807102 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase I Trial of Tumor-Associated Lymph Node T-Cell Injection With Advanced Malignant Solid Tumors
NCT06716619 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Research of NK Cell Infusion Combined With Chemotherapy in the Treatment of Non-small Cell Lung Cancer
NCT02734524 ·Status: UNKNOWN ·Phase: PHASE2
-
Autologous Tumor-Infiltrating Lymphocyte Injection(GT201) for Treatment of Patients With Advanced Lung Cancer
NCT06519669 ·Status: TERMINATED ·Phase: NA
-
Treatment of Advanced Solid Tumors With TSA-CTL(Tumor Specific Antigen-Induced Cytotoxic T Lymphocytes)
NCT02959905 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Biomarker Development for Lung Cancer Treated With Immune Checkpoint Inhibitors
NCT05055908 ·Status: RECRUITING ·Phase: PHASE3
-
Therapeutic Vaccine Plus PD-1 Knockout in Prostate Cancer Treatment
NCT03525652 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Combination Immunotherapy Targeting Sarcomas
NCT04433221 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Programmed Death-1 (PD-1) Antibody Combined With Chemoradiotherapy in High-risk Recurrent Nasopharyngeal Carcinoma
NCT03930498 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Local Therapy in Advanced NSCLC With Non-progressive Disease (PD) After First Line Therapy
NCT03046316 ·Status: RECRUITING ·Phase: NA
-
A Study of GC203 TIL in Advanced Solid Tumors (NF)
NCT07256756 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Study of Tumor Neoantigen-specific T Cells in the Treatment of Advanced Solid Tumors
NCT06431529 ·Status: RECRUITING ·Phase: EARLY_PHASE1