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The Effect of Statin Treatment on Trained Innate Immunity

NCT03354156 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2017-11-27

No results posted yet for this study

Summary

The innate immune system plays a pivotal role in the development and progression of atherosclerosis. Recently, it was reported that monocytes can develop a long-lasting immunological memory after stimulation with various microorganisms, which has been termed 'trained innate immunity'. This memory is induced by epigenetic reprogramming, in particular trimethylation of lysine 4 at histone 3 (H3K4me3).

In this study, the investigators aim to investigate the immunophenotype of circulating monocytes in patients with elevated LDL cholesterol levels and the effect of statins on this phenotype.

Conditions

Interventions

DRUG

statin treatment

The patients with elevated LDL receive statin treatment in the context of normal patient care (so this is NOT an intervention of the study)

Sponsors & Collaborators

  • AIDS Malignancy Consortium

    collaborator NETWORK

  • Erasmus Medical Center

    collaborator OTHER

  • Radboud University Medical Center

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2016-11-30
Completion
2016-12-31

Countries

  • Netherlands

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03354156 on ClinicalTrials.gov