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Improving the Diagnosis of Common Variable Immune Deficiency

NCT03335605 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 24

Last updated 2026-04-20

No results posted yet for this study

Summary

This is an observational, case-control study with a single blood draw among two cohorts, patients with antibody deficiency (e.g., CVID) and healthy controls. Samples will be analyzed by mass cytometry (CyTOF) to examine the major signaling pathways of all circulating innate and adaptive immune cell types, as well as whole exome sequencing. The goal is to improve our general understanding of the human immune response to infections and the diagnosis of CVID.

Conditions

  • CVI - Common Variable Immunodeficiency

Sponsors & Collaborators

Principal Investigators

  • Manish J Butte, MD PhD · University of California, Los Angeles

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-01
Primary Completion
2021-12-31
Completion
2022-06-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03335605 on ClinicalTrials.gov