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Gastric Acid Suppression and Probiotic Colonization

NCT03327051 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 39

Last updated 2020-03-11

Study results available
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Summary

Probiotics are over-the-counter dietary products with microorganisms that are generally consumed for health benefit. However, the durability of these microorganisms is unclear, particularly when they pass through the highly acidic environment of the stomach. We will test the colonization of these microorganisms among individuals who consume probiotics with and without acid suppression therapy.

Conditions

  • Probiotics

Interventions

DRUG

Omeprazole

Proton pump inhibitor (PPI) that suppresses gastric acid secretion

DIETARY_SUPPLEMENT

VSL #3

Probiotics

DRUG

Placebo

Placebo to match omeprazole

Sponsors & Collaborators

Principal Investigators

  • Aida Habtezion, M.D. · Stanford University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-03-20
Primary Completion
2018-12-30
Completion
2018-12-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03327051 on ClinicalTrials.gov