Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori Infection

Summary

Current studies have primarily focused on comparing the advantages and disadvantages of P-CAB and PPI drugs, with little comparison between different P-CAB drugs or between regimens with varying drug combinations and treatment durations.

This study aims to evaluate the clinical effectiveness of vonoprazan-based H. pylori eradication therapy and compare it to that of conventional PPI based therapy in clinical practice.

Conditions

• H Pylori

Interventions

DRUG

Clarithromycin 500 mg

Clarithromycin 500 mg orally twice daily for 14 days

DRUG

Amoxicillin 1 g

Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks

DRUG

Omeprazole 40 mg

Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks

DRUG

Clarithromycin 500 mg

Clarithromycin 500 mg orally twice daily for 14 days

DRUG

Amoxicillin 1 g

Amoxicillin 1 g orally twice daily for 14 days

DRUG

Vonoprazan 20 mg

Vonoprazan 20 mg orally twice daily for 14 days, then 20 mg once daily for 4 weeks

DRUG

Levofloxacin 500 mg

Levofloxacin 500 mg orally once daily for 14 days

DRUG

Amoxicillin 1 g

Amoxicillin 1 g orally twice daily for 14 days

DRUG

Omeprazole 40 mg

Omeprazole 40 mg orally twice daily for 14 days, then 40 mg once daily for 4 weeks

DRUG

Levofloxacin 500 mg

Levofloxacin 500 mg orally once daily for 14 days

DRUG

Amoxicillin 1 g

Amoxicillin 1 g orally twice daily for 14 days

DRUG

Vonoprazan 20 mg

Vonoprazan 20 mg orally twice daily for 14 days, then 20 mg once daily for 4 weeks

Sponsors & Collaborators

• Rehman Medical Institute - RMI

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

12 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-07-31

Primary Completion

2026-02-28

Completion

2026-02-28

Countries

• Pakistan

Study Locations