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Sevoflurane, Propofol and Desflurane on POD/POCD

NCT03326960 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2020-10-22

No results posted yet for this study

Summary

The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and severity of POD/POCD, and POD/POCD is associated with retinal nerve fiber layer (RNFL) thickness, as well as Serum level of vitamin B12, folic acid, homocysteine and human myeloid differentiation protein-2 (MD-2s). The investigators plan to perform the studies in 300 participants at Shanghai 10th People's Hospital.

Conditions

  • Sevoflurane
  • Propofol
  • Desflurane

Interventions

DRUG

Sevoflurane

Anesthesia maintenance with sevoflurane guided by Narcrotrend index monitoring.

DRUG

Propofol

Anesthesia maintenance with propofol guided by Narcrotrend index monitoring.

DRUG

Desflurane

Anesthesia maintenance with desflurane guided by Narcrotrend index monitoring.

Sponsors & Collaborators

  • Massachusetts General Hospital

    collaborator OTHER

  • Shanghai 10th People's Hospital

    lead OTHER

Principal Investigators

  • Yuan Shen, M.D.,Ph.D · Shanghai 10th People's Hospital

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-01
Primary Completion
2021-06-30
Completion
2021-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03326960 on ClinicalTrials.gov