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Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery

NCT04707794 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 270

Last updated 2026-04-27

No results posted yet for this study

Summary

Postoperative delirium (POD) is the most common adverse neurologic complication that can occur in patients of any age. Its incidence varies across age groups and is substantially influenced by patient-related risk factors. POD occurs in 17%-61% of major surgical procedures. Several risk factors which contribute to the development of POD include age more than 60 years, pre-existing cognitive dysfunction, presence of comorbidities, sensorial deficits, malnutrition, polypharmacy, impaired physical mobility and frailty. Postoperative delirium has several wide ranging and adverse outcomes that are consistently associated with delirium such as mortality, increased length of hospital stay, and increased hospital costs. A recently devised tool for rapid assessment of delirium is the 4 A's test. It has now been validated for identifying delirium in the surgical population. The proposed prospective observational study will be conducted on 150 patients belonging to ASA Physical Status I-III of either sex, scheduled to undergo non-cardiac surgery under general anaesthesia (GA), requiring at least 24 hours of postoperative inpatient care. This prospective, observational study aims to evaluate the incidence, risk factors and outcomes of postoperative delirium in elderly patients more than 65 years of age undergoing non-cardiac surgery.

Conditions

  • Postoperative Delirium

Interventions

DRUG

Sevoflurane

Sevoflurane delivery will will be titrated to maintain anaesthesia depth of 50 (BIS score) using bispectral (BIS) index monitioring

DRUG

Desflurane

Desflurane delivery will be titrated to maintain anaesthesia depth of 50 (BIS score) using bispectral (BIS) index monitioring

Sponsors & Collaborators

  • Sir Ganga Ram Hospital

    lead OTHER

Principal Investigators

  • Nitin Sethi, MBBS, DNB · Sir Ganga Ram Hospital

  • Bimla Sharma, MBBS, DGO, MD, FICA, MHA · Sir Ganga Ram Hospital

  • Chand Sahai, MBBS, DA, MD · Sir Ganga Ram Hospital

  • Jayashree Sood, MBBS, MD, FFRCA, PGDHHM, FICA · Sir Ganga Ram Hospital

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-14
Primary Completion
2028-08-31
Completion
2028-09-30

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04707794 on ClinicalTrials.gov