How Different Sedatives Affect Hip Fracture Patient's Postoperative Delirium

Summary

the hypothesis is that Dexmedetomidine seems to decrease incidence of post-operative delirium . one possible mechanism is that Dex have a minor influence on cognition, since it has no effect on GABA receptor，another is that Dex could induce a sleep similar to natural sleep, thereby decreasing sleep deprivation and circadian rhythm disorder in post-operative patients.

In this study , investigators devise the two different sedatives(Dexmedetomidine and Propofol)'influence on postoperative delirium in hip fracture elderly participants under spinal anesthesia

Conditions

• Delirium in Old Age

Interventions

DRUG

Dexmedetomidine Hydrochloride

Dexmedetomidine is given to patients during spinal anesthesia at the dose of 0.5 μg/kg，adjusted the dose to keep BIS between 70-80 until 30 minutes before the end of surgery

DRUG

Propofol

Propofol is given with an initial ratio of 2-10mg/kg/h, when the operation starts，adjust the propofol's dose to keep BIS between 70-80 before the end of surgery

Sponsors & Collaborators

• First Affiliated Hospital of Guangxi Medical University

  collaborator OTHER

• The Second Affiliated Hospital of Harbin Medical University

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Qianfoshan Hospital

  collaborator OTHER

• Shanghai 6th People's Hospital

  collaborator OTHER

• Tang-Du Hospital

  collaborator OTHER

• Second Hospital of Shanxi Medical University

  collaborator OTHER

• The First Affiliated Hospital of Soochow University

  collaborator OTHER

• Shanghai Changzheng Hospital

  collaborator OTHER

• The Fuzhou No 2 Hospital

  collaborator OTHER

• Foshan Hospital of Traditional Chinese Medicine

  collaborator OTHER

• Beijing Jishuitan Hospital

  collaborator OTHER

• Shanghai Zhongshan Hospital

  lead OTHER

Principal Investigators

• Xue ZhangGang, doctor · Anesthesiology Department of Shanghai Zhongshan Hospital

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

65 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-01-01

Primary Completion

2018-12-30

Completion

2019-06-30